Effect of Probiotic-Fortified Infant Formula on Infant Gut Health and Microbiota Modulation

Compared to infant formula, breast milk is the best source of nutrition for infants; it not only improves neonatal intestinal function, but also regulates immune system and gut microbiota composition. However, probiotic-fortified formula may further enhance environment by overcoming limitations traditional formula. We investigated probiotic administration one month comparing 118 Korean infants into following three groups: in each group fed with (50), (35), or placebo formula-fed (33). Probiotic improved stool consistency defecation frequency compared group. The helped maintaining level secretory immunoglobulin A (sIgA), which had remarkably decreased over time (compared weeks 0 4). Moreover, acidity considerably increased butyrate concentration. Furthermore, fecal was evaluated at 4. microbial composition distinct between groups, abundance health-promoting bacteria In summary, supplementation can help optimize environment, composition, metabolic activity microbiota, mimicking those milk.